Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 143
interventional 108
Observational 28
Registry 7

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 32
Drug|placebo 32
Behavioral 11
Device 7
Other 7
Dietary Supplement 4
Device|Other 3
Biological 2
Procedure 2
Behavioral|Device|Diagnostic Test 1
Behavioral|Drug 1
Behavioral|Procedure 1
Biological|placebo 1
Combination Product 1
Dietary Supplement|Other|placebo 1
Dietary Supplement|placebo 1
Drug|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 50
Italy 10
France 8
NA 8
Taiwan 4
Brazil 3
Turkey 3
United Kingdom 3
Australia 2
Korea, Republic of 2
Malaysia 2
Australia|Belgium|Canada|France|Italy|Spain 1
Austria|Belgium|France|Germany|Netherlands 1
Austria|Belgium|France|Germany|Netherlands|United Kingdom 1
Austria|Germany|Italy 1
Austria|Germany|Netherlands|United Kingdom 1
Belgium|France|Germany|Spain 1
Belgium|France|Italy|Spain 1
Israel 1
Netherlands 1
United States|Australia|Austria|Italy|United Kingdom 1
United States|Australia|Belgium|Germany|India|Israel|Italy|Norway|Poland|Spain|Tunisia|United Kingdom 1
United States|Australia|Belgium|Germany|India|Poland|Spain 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 77
2 7
3 5
4 4
5 2
6 4
7 1
8 1
11 2
13 1
15 1
18 1
21 1
22 1

Phase

Phase Study_Count
N/A 39
Phase 2 27
Phase 3 18
Phase 1/Phase 2 7
Phase 1 6
Phase 4 5
Early Phase 1 3
Phase 2/Phase 3 3

Number of Arms

Number_of_Arms Count_of_Studies
1 29
2 58
3 7
4 5
5 2
6 1
9 1
NA 5

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 10.0 6.00000 1.00000 7.00000 4.00000 60.00000 19.0 1.0
1st Qu. 10.5 16.50000 13.75000 12.00000 11.00000 61.00000 38.5 27.0
Median 11.0 20.00000 24.00000 19.00000 24.00000 62.00000 60.0 30.0
Mean 11.0 42.23077 34.66667 29.57143 34.51852 87.66667 85.0 55.2
3rd Qu. 11.5 40.50000 42.50000 38.50000 41.00000 101.50000 90.5 52.0
Max. 12.0 264.00000 100.00000 80.00000 172.00000 141.00000 232.0 166.0

Trial Group Type

group_type Group_Count
Experimental 123
Placebo Comparator 36
Active Comparator 32
Other 10
No Intervention 5
Sham Comparator 5
NA 5

Intervention Model

intervention_model Study_Count
Parallel Assignment 53
Single Group Assignment 35
Crossover Assignment 15
NA 3
Factorial Assignment 2

Primary Purpose

primary_purpose Study_Count
Treatment 93
Supportive Care 7
Basic Science 3
Diagnostic 2
Other 2
Screening 1

Observational Studies

Studies by Country

Country Study_Count
United States 18
France 5
Israel 2
Brazil 1
China 1
United States|India|Israel|Italy 1

Sites per Study

Site_count Study_Count
1 23
2 2
4 1
5 1
12 1

Enrollment Metrics

Measure Observational
Min 14.00
1st Qu 38.00
Median 97.50
Mean 180.75
3rd Qu 153.75
Max 1500.00

Observation Model

observational_model Study_Count
Cohort 11
Case-Control 6
NA 5
Case-Only 3
Case Control 1
Family-Based 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 13
Cross-Sectional 8
NA 4
Retrospective 3

Registries

Studies by Country

Country Study_Count
United States 2
Austria|Belgium|France|Germany|Italy|Spain|United Kingdom 1
Austria|Germany|Italy|Netherlands|Norway 1
Hong Kong 1
United States|Australia 1
United States|Australia|Canada|New Zealand 1

Sites per Study

Site_count Study_Count
1 2
2 1
3 1
12 2
14 1

Enrollment Metrics

Measure Registries
Min 70.000
1st Qu 155.000
Median 300.000
Mean 3297.143
3rd Qu 1200.000
Max 20000.000

Registry Model

observational_model Study_Count
Cohort 4
Case-Control 2
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 7

Follow-up

target_duration Study_Count
1 Day 1
10 Years 1
100 Years 1
15 Years 1
2 Years 1
20 Years 1
3 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT02593773 Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich’s Ataxia Study https://ClinicalTrials.gov/show/NCT02593773 Completed Horizon Pharma Ireland, Ltd., Dublin Ireland 2017-03-21
NCT03347344 Clinical Trial With Riluzole in Spinocerebellar Ataxia Type 2 (ATRIL) https://ClinicalTrials.gov/show/NCT03347344 Recruiting Assistance Publique - Hôpitaux de Paris 2019-01-17
NCT03202771 Randomized Controlled Trial of Home Versus Office Biofeedback for Constipation https://ClinicalTrials.gov/show/NCT03202771 Completed Augusta University 2010-12-31
NCT03120013 Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia https://ClinicalTrials.gov/show/NCT03120013 Completed Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 2018-12-01
NCT03109626 Docosahexaenoic Acid (DHA) Replacement for Treatment in Spinocerebellar Ataxia 38 https://ClinicalTrials.gov/show/NCT03109626 Completed Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 2015-09-17
NCT02977377 The Effects Of Whole Body Vibration On Postural Control In Patients With Ataxia https://ClinicalTrials.gov/show/NCT02977377 Completed Hacettepe University 2017-10-31
NCT02960893 Trial in Adult Subjects With Spinocerebellar Ataxia https://ClinicalTrials.gov/show/NCT02960893 Active, not recruiting Biohaven Pharmaceuticals, Inc. 2017-08-18
NCT02900508 Virtual Reality-based Training in Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT02900508 Completed National Yang Ming University 2015-07-31
NCT02887703 Augmenting Balance in Individuals With Cerebellar Ataxias https://ClinicalTrials.gov/show/NCT02887703 Completed University of Michigan 2018-01-31
NCT02874911 Coordination Training With Complete Body Video Games in Children and Adults With Degenerative Ataxias https://ClinicalTrials.gov/show/NCT02874911 Completed University Hospital Tuebingen 2014-09-30
NCT02840669 A Study to Characterize the Cardiac Phenotype of Individuals With Friedreich’s Ataxia (CARFA Study) https://ClinicalTrials.gov/show/NCT02840669 Completed Adverum Biotechnologies, Inc. 2018-06-30
NCT02797080 Long-Term Safety Extension Study of ACTIMMUNE® (Interferon γ-1b) in Children and Young Adults With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT02797080 Completed Horizon Pharma Ireland, Ltd., Dublin Ireland 2017-03-31
NCT02770807 EDS in Ataxia Telangiectasia Patients https://ClinicalTrials.gov/show/NCT02770807 Recruiting Erydel 2020-11-30
NCT02741440 Natural History of Spinocerebellar Ataxia Type 7 (SCA7) https://ClinicalTrials.gov/show/NCT02741440 Recruiting National Institutes of Health Clinical Center (CC) 2025-01-01
NCT02733679 Response of Individuals With Ataxia-Telangiectasia to Metformin and Pioglitazone https://ClinicalTrials.gov/show/NCT02733679 Completed NHS Tayside 2017-08-30
NCT02705547 Rosuvastatin (Crestor) in Friedreich Ataxia https://ClinicalTrials.gov/show/NCT02705547 Completed Children’s Hospital of Philadelphia 2017-08-04
NCT02660112 (+) Epicatechin to Treat Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT02660112 Completed Mayo Clinic 2018-12-30
NCT04102501 A Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT04102501 Recruiting Retrotope, Inc. 2021-02-28
NCT02488031 Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia https://ClinicalTrials.gov/show/NCT02488031 Completed University of Florida 2019-01-17
NCT02445794 A First in Human Study of RT001 in Patients With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT02445794 Completed Retrotope, Inc. 2016-06-30
NCT02424435 Methylprednisolone Treatment of Friedreich Ataxia https://ClinicalTrials.gov/show/NCT02424435 Completed Children’s Hospital of Philadelphia 2017-12-31
NCT02353299 Assess the Effect of Zolpidem, Silenor & Placebo on Arousability, Ataxia/Balance & Cognition in Healthy Volunteers https://ClinicalTrials.gov/show/NCT02353299 Completed Currax Pharmaceuticals 2016-01-31
NCT02345200 Body Composition and Hormonal Status in Ataxia Telangiectasia https://ClinicalTrials.gov/show/NCT02345200 Completed Johann Wolfgang Goethe University Hospital 2014-04-30
NCT02345135 Susceptibility to Infections in Ataxia Telangiectasia https://ClinicalTrials.gov/show/NCT02345135 Completed Johann Wolfgang Goethe University Hospital 2016-01-31
NCT02333305 Evolution of Albumin on AOA1 Patients Supplemented With Coenzyme Q10 https://ClinicalTrials.gov/show/NCT02333305 Completed Assistance Publique - Hôpitaux de Paris 2017-09-30
NCT02323243 Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter Dyssynergia https://ClinicalTrials.gov/show/NCT02323243 Completed Hospices Civils de Lyon 2016-05-31
NCT02255435 RTA 408 Capsules in Patients With Friedreich’s Ataxia - MOXIe https://ClinicalTrials.gov/show/NCT02255435 Active, not recruiting Reata Pharmaceuticals, Inc. 2019-10-03
NCT04039048 Effect of ctDCS During Balance Training on Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT04039048 Recruiting Universidade Federal de Pernambuco 2020-02-29
NCT03917225 A Clinical Study to Evaluate the Effect of MIN-102 on the Progression of Friedreich’s Ataxia in Male and Female Patients https://ClinicalTrials.gov/show/NCT03917225 Active, not recruiting Minoryx Therapeutics, S.L. 2020-03-31
NCT01303406 Patient Reported Outcomes in Friedreich’s Ataxia Patients After Withdrawal From Treatment With Idebenone (PROTI) https://ClinicalTrials.gov/show/NCT01303406 Completed Santhera Pharmaceuticals 2012-07-31
NCT01307176 Exercise Training Program for Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT01307176 Completed Hugo W. Moser Research Institute at Kennedy Krieger, Inc. 2014-02-28
NCT03879018 Retraining Reaching in Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT03879018 Recruiting Hugo W. Moser Research Institute at Kennedy Krieger, Inc. 2021-04-01
NCT01983631 The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia https://ClinicalTrials.gov/show/NCT01983631 Completed Chang Gung University 2013-03-31
NCT01965327 Interferon Gamma-1b in Friedreich Ataxia (FRDA) https://ClinicalTrials.gov/show/NCT01965327 Completed Children’s Hospital of Philadelphia 2014-03-31
NCT01964664 Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments https://ClinicalTrials.gov/show/NCT01964664 Completed Oregon Health and Science University 2016-10-31
NCT01898884 Safety and Pharmacology Study of VP 20629 in Adults With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT01898884 Completed Shire 2015-06-18
NCT01811706 Dalfampridine and Gait in Spinocerebellar Ataxias https://ClinicalTrials.gov/show/NCT01811706 Completed University of Florida 2013-12-31
NCT01728064 Safety and Efficacy of EPI-743 in Patients With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT01728064 Completed Edison Pharmaceuticals Inc 2015-10-31
NCT01716221 An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxia https://ClinicalTrials.gov/show/NCT01716221 Completed University of Colorado, Denver 2013-03-31
NCT04107740 C-Trelin Orally Disintegrated(OD) Tablet 5mg in Ataxia Due to Spinocerebellar Degeneration https://ClinicalTrials.gov/show/NCT04107740 Recruiting Chem Tech Research Incorporation 2020-06-30
NCT01649687 Treatment of Cerebellar Ataxia With Mesenchymal Stem Cells https://ClinicalTrials.gov/show/NCT01649687 Completed National Yang Ming University 2014-01-31
NCT03408080 An Open Pilot Trial of BHV-4157 https://ClinicalTrials.gov/show/NCT03408080 Active, not recruiting University of California, Los Angeles 2021-04-30
NCT01493973 Efficacy Study of Epoetin Alfa in Friedreich Ataxia https://ClinicalTrials.gov/show/NCT01493973 Completed Federico II University 2014-10-31
NCT00631202 Efficacy of Epoetin Alfa in Patients With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00631202 Completed Federico II University 2008-12-31
NCT01350440 Safety and Efficacy of Intravenous Immune Globulin in Treating Spinocerebellar Ataxia https://ClinicalTrials.gov/show/NCT01350440 Completed University of South Florida 2013-07-31
NCT01339884 A Study of Resveratrol as Treatment for Friedreich Ataxia https://ClinicalTrials.gov/show/NCT01339884 Completed Murdoch Childrens Research Institute 2012-08-31
NCT04428567 Treadmill Training in Fragile X-associated Tremor/Ataxia Syndrome https://ClinicalTrials.gov/show/NCT04428567 Recruiting Rush University Medical Center 2021-07-30
NCT04426149 Clinical Effects of Oral Trehalose In Patients With Spinocerebellar Ataxia 3 https://ClinicalTrials.gov/show/NCT04426149 Completed National University of Malaysia 2018-09-07
NCT04399265 Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3 https://ClinicalTrials.gov/show/NCT04399265 Recruiting National University of Malaysia 2021-09-30
NCT04183647 Investigation of Acute Effects of Local Vibration and Whole-Body Vibration Applications https://ClinicalTrials.gov/show/NCT04183647 Completed Hacettepe University 2019-05-01
NCT04176991 Single Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT04176991 Recruiting Larimar Therapeutics, Inc. 2020-09-30
NCT04153110 Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia https://ClinicalTrials.gov/show/NCT04153110 Recruiting Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 2020-09-01
NCT03972202 The Role of Cerebellum in Speech https://ClinicalTrials.gov/show/NCT03972202 Recruiting University of California, San Francisco 2022-01-01
NCT03945682 The ASsessment and Physiotherapy managEment of Ataxia in Children Following Surgical Resection of Posterior Fossa Tumour https://ClinicalTrials.gov/show/NCT03945682 Recruiting Alder Hey Children’s NHS Foundation Trust 2020-12-31
NCT03933163 Micronised Resveratrol as a Treatment for Friedreich Ataxia https://ClinicalTrials.gov/show/NCT03933163 Recruiting Murdoch Childrens Research Institute 2020-12-31
NCT03932669 Effect of Nilotinib in Cerebellar Ataxia Patients https://ClinicalTrials.gov/show/NCT03932669 Active, not recruiting Seoul National University Hospital 2020-04-30
NCT03901638 Tllsh2910 for Ataxia and Gut Microbiota Alteration in Patients of Multiple System Atrophy https://ClinicalTrials.gov/show/NCT03901638 Recruiting National Taiwan University Hospital 2021-11-15
NCT03888664 Open Trail of γIFN for Friedreich Ataxia https://ClinicalTrials.gov/show/NCT03888664 Completed IRCCS Eugenio Medea 2017-12-31
NCT03817086 Physical and Mental Practice for Bimanual Coordination Rehabilitation https://ClinicalTrials.gov/show/NCT03817086 Recruiting Kessler Foundation 2020-05-30
NCT03759678 N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T) https://ClinicalTrials.gov/show/NCT03759678 Recruiting IntraBio Inc 2020-07-01
NCT03745248 Aerobic Exercise, Balance Training, and Ataxia https://ClinicalTrials.gov/show/NCT03745248 Completed Columbia University 2019-06-09
NCT03703830 tDCS Associated With Locomotor Training on Functional Mobility of Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT03703830 Recruiting Universidade Federal de Pernambuco 2020-01-31
NCT03701776 Ataxia, Imaging, and Exercise Disease Using MRI and Gait Analysis https://ClinicalTrials.gov/show/NCT03701776 Recruiting Columbia University 2021-06-30
NCT03701399 Troriluzole in Adult Subjects With Spinocerebellar Ataxia https://ClinicalTrials.gov/show/NCT03701399 Recruiting Biohaven Pharmaceuticals, Inc. 2020-10-31
NCT03687190 Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients https://ClinicalTrials.gov/show/NCT03687190 Completed Changhua Christian Hospital 2015-12-02
NCT03619772 EMG Training for Altering Activation Patterns After Stroke https://ClinicalTrials.gov/show/NCT03619772 Active, not recruiting Shirley Ryan AbilityLab 2020-10-31
NCT03607058 The Effects of Game Based Exercise Training on Balance and Postural Control in Patients With Ataxia https://ClinicalTrials.gov/show/NCT03607058 Recruiting Hacettepe University 2018-09-30
NCT03563053 Open-label, Long-term, Extension Treatment Using Intra-Erythrocyte Dexamethasone Sodium Phosphate in Patients With Ataxia Telangiectasia Who Participated in the IEDAT-02-2015 Study https://ClinicalTrials.gov/show/NCT03563053 Recruiting Erydel 2020-08-31
NCT01255358 Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Teleangiectasia Patients https://ClinicalTrials.gov/show/NCT01255358 Completed Erydel 2011-09-30
NCT01104649 Efficacy of Riluzole in Hereditary Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT01104649 Completed S. Andrea Hospital 2014-02-28
NCT01096082 Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 https://ClinicalTrials.gov/show/NCT01096082 Completed Hospital de Clinicas de Porto Alegre 2012-12-31
NCT01016366 Safety Study of Carbamylated Erythropoietin to Treat Patients With the Neurodegenerative Disorder Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT01016366 Completed H. Lundbeck A/S 2011-03-31
NCT00998634 Safety and Tolerability of Lithium in Spinocerebellar Ataxia 2 (SCA2) https://ClinicalTrials.gov/show/NCT00998634 Completed Federico II University 2012-11-30
NCT00993967 Long-Term Safety and Tolerability of Idebenone in Friedreich’s Ataxia Patients (MICONOS Extension) https://ClinicalTrials.gov/show/NCT00993967 Completed Santhera Pharmaceuticals 2012-06-30
NCT00992771 Study to Determine the Safety and Tolerability of Varenicline (Chantix®) in Treating Spinocerebellar Ataxia Type 3 https://ClinicalTrials.gov/show/NCT00992771 Completed University of South Florida 2011-04-30
NCT00957216 Coenzyme Q10 in Adult-Onset Ataxia https://ClinicalTrials.gov/show/NCT00957216 Completed The University of Texas Medical Branch, Galveston 2009-08-31
NCT00950196 Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia https://ClinicalTrials.gov/show/NCT00950196 Completed Sheba Medical Center 2009-11-30
NCT00905268 A Study of Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich’s Ataxia (FRDA) Patients https://ClinicalTrials.gov/show/NCT00905268 Completed Santhera Pharmaceuticals 2010-01-31
NCT00897221 A Study Investigating the Long-term Safety and Efficacy of Deferiprone in Patients With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00897221 Completed ApoPharma 2011-03-31
NCT02829268 A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome https://ClinicalTrials.gov/show/NCT02829268 Recruiting Washington University School of Medicine 2020-12-31
NCT02603926 Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone https://ClinicalTrials.gov/show/NCT02603926 Completed University of California, Davis 2016-12-31
NCT02197104 Citocoline for Treatment of FXTAS https://ClinicalTrials.gov/show/NCT02197104 Completed Rush University Medical Center 2017-01-31
NCT02103075 Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia https://ClinicalTrials.gov/show/NCT02103075 Completed Chang Gung University 2005-10-31
NCT01975909 Transcranial Magnetic Stimulation in Spino-Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT01975909 Completed Beth Israel Deaconess Medical Center 2016-10-31
NCT00824512 Efficacy of EGb761 in Patients Suffering From Friedreich Ataxia https://ClinicalTrials.gov/show/NCT00824512 Completed Ipsen 2011-10-31
NCT04192136 NAD+ and Exercise in FA https://ClinicalTrials.gov/show/NCT04192136 Recruiting Children’s Hospital of Philadelphia 2024-12-31
NCT02035020 A Phase IIa Trial to Test Safety and Efficacy Interferon Gamma Treatment in Elevating Frataxin Levels in FRDA Patients https://ClinicalTrials.gov/show/NCT02035020 Completed Azienda Policlinico Umberto I 2014-07-30
NCT00811681 Effect of Pioglitazone Administered to Patients With Friedreich’s Ataxia: Proof of Concept https://ClinicalTrials.gov/show/NCT00811681 Completed Assistance Publique - Hôpitaux de Paris 2013-03-31
NCT03962114 Effects of Vitamin B3 in Patients With Ataxia Telangiectasia https://ClinicalTrials.gov/show/NCT03962114 Enrolling by invitation Radboud University 2019-12-01
NCT01962363 EPI-743 in Friedreich’s Ataxia Point Mutations https://ClinicalTrials.gov/show/NCT01962363 Completed University of South Florida 2016-06-30
NCT03286686 Sensori-motor and Perceptual Functions of the PPC. https://ClinicalTrials.gov/show/NCT03286686 Recruiting Hospices Civils de Lyon 2024-02-22
NCT03214588 Efficacy, Tolerability, and Pharmacokinetics of Multiple Doses of Oral TAK-831 in Adults With Friedreich Ataxia https://ClinicalTrials.gov/show/NCT03214588 Completed Takeda 2018-12-27
NCT01035671 Safety and Efficacy Study of A0001 in Subjects With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT01035671 Completed Penwest Pharmaceuticals Co. 2011-02-28
NCT00697073 Study to Assess the Safety and Tolerability of Idebenone in the Treatment of Friedreich’s Ataxia Patients https://ClinicalTrials.gov/show/NCT00697073 Completed Santhera Pharmaceuticals 2010-05-31
NCT00683943 Lithium Treatment for Patients With Spinocerebellar Ataxia Type I https://ClinicalTrials.gov/show/NCT00683943 Completed National Institutes of Health Clinical Center (CC) 2010-02-25
NCT00656409 Conjugate Pneumococcal Vaccine in Ataxia Telangiectasia (AT) https://ClinicalTrials.gov/show/NCT00656409 Completed Institute of Child Health NA
NCT00640003 Baclofen Treatment of Ataxia Telangiectasia https://ClinicalTrials.gov/show/NCT00640003 Completed Johns Hopkins University 2011-02-28
NCT00584948 Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome https://ClinicalTrials.gov/show/NCT00584948 Completed University of California, Davis 2012-09-30
NCT00537680 Study to Assess the Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00537680 Completed Santhera Pharmaceuticals 2009-04-30
NCT00530127 A Study Investigating the Safety and Tolerability of Deferiprone in Patients With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00530127 Completed ApoPharma 2009-07-31
NCT00272272 Fall Prevention in a Geriatric Nursing Home Setting Using the Music of Nolwenn Leroy https://ClinicalTrials.gov/show/NCT00272272 Completed Carrick Institute for Graduate Studies 2006-10-31
NCT00229632 Idebenone to Treat Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00229632 Completed National Institutes of Health Clinical Center (CC) 2007-12-17
NCT00224640 Iron-Chelating Therapy and Friedreich Ataxia https://ClinicalTrials.gov/show/NCT00224640 Completed Assistance Publique - Hôpitaux de Paris 2008-03-31
NCT00202397 Effect of Riluzole as a Symptomatic Approach in Patients With Chronic Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT00202397 Completed S. Andrea Hospital 2008-06-30
NCT00187057 Study for Treatment of Cancer in Children With Ataxia-telangiectasia https://ClinicalTrials.gov/show/NCT00187057 Completed St. Jude Children’s Research Hospital 2006-08-31
NCT02415127 Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT02415127 Completed Horizon Pharma Ireland, Ltd., Dublin Ireland 2016-11-30
NCT00078481 Phase 1 Trial of Idebenone to Treat Patients With Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00078481 Completed National Institutes of Health Clinical Center (CC) NA
NCT00015808 Safety Study of Idebenone to Treat Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT00015808 Completed National Institutes of Health Clinical Center (CC) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03122925 TCA Cycle in the Dentate in Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT03122925 Enrolling by invitation University of Minnesota 2020-12-31
NCT02936531 Brain Network Activation and Gait and Posture in FXTAS https://ClinicalTrials.gov/show/NCT02936531 Recruiting Sheba Medical Center 2018-10-31
NCT02497534 Biomarkers in Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT02497534 Recruiting University of Florida 2021-06-30
NCT02316314 Characterization of the Cardiac Phenotype of Friedreich’s Ataxia (FRDA) https://ClinicalTrials.gov/show/NCT02316314 Active, not recruiting Weill Medical College of Cornell University 2023-08-31
NCT02179333 Preliminary Study of the Scale To Assess Ataxia and Neurologic Dysfunction (STAND) https://ClinicalTrials.gov/show/NCT02179333 Completed University of South Florida 2016-06-30
NCT01942850 International Ataxia Rating Scale in Younger Patients https://ClinicalTrials.gov/show/NCT01942850 Completed Erydel 2014-05-31
NCT01934998 Parkinsonism in Spinocerebellar Ataxia Type 6 https://ClinicalTrials.gov/show/NCT01934998 Completed University of Chicago 2015-04-30
NCT01776164 Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT01776164 Enrolling by invitation University of Minnesota 2020-12-31
NCT01488461 Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias https://ClinicalTrials.gov/show/NCT01488461 Completed Assistance Publique - Hôpitaux de Paris 2014-10-31
NCT01470729 Biomarkers in Autosomal Dominant Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT01470729 Completed Assistance Publique - Hôpitaux de Paris 2015-12-31
NCT04346238 Characterization of the Interruptions of the GAA Expansion and Study of Their Influence on the Severity of Friedreich’s Ataxia https://ClinicalTrials.gov/show/NCT04346238 Active, not recruiting University Hospital, Montpellier 2021-03-30
NCT04288128 Integrated Functional Evaluation of the Cerebellum https://ClinicalTrials.gov/show/NCT04288128 Recruiting Institut National de la Santé Et de la Recherche Médicale, France 2021-05-31
NCT04268147 Instrumented Data Exchange for Ataxia Study https://ClinicalTrials.gov/show/NCT04268147 Recruiting University of Chicago 2021-12-31
NCT04255680 A Study to Assess Variation in Potential Biomarkers in Friedreich Ataxia https://ClinicalTrials.gov/show/NCT04255680 Enrolling by invitation Larimar Therapeutics, Inc. 2020-06-30
NCT04229823 Natural History of Oculomotor Neurophysiology in Ataxic and Pre-ataxic Carriers of SCA3/MJD https://ClinicalTrials.gov/show/NCT04229823 Active, not recruiting Hospital de Clinicas de Porto Alegre 2020-12-31
NCT04099914 Validation of a Clinical Algorithm for the Diagnosis of Recessive Ataxias https://ClinicalTrials.gov/show/NCT04099914 Recruiting University Hospital, Montpellier 2021-12-15
NCT04037189 Treatment of Leukemia and Lymphoma in Children With Ataxia Telangiectasia https://ClinicalTrials.gov/show/NCT04037189 Recruiting Rabin Medical Center 2021-07-28
NCT04010214 A Registered Cohort Study on Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT04010214 Recruiting First Affiliated Hospital of Fujian Medical University 2039-12-31
NCT03769961 Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect https://ClinicalTrials.gov/show/NCT03769961 Recruiting Oregon Health and Science University 2020-12-31
NCT03487367 Clinical Trial Readiness for SCA1 and SCA3 https://ClinicalTrials.gov/show/NCT03487367 Recruiting The Methodist Hospital System 2022-12-31
NCT01060371 Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias https://ClinicalTrials.gov/show/NCT01060371 Recruiting University of Florida 2021-05-31
NCT03624374 Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) https://ClinicalTrials.gov/show/NCT03624374 Recruiting Hugo W. Moser Research Institute at Kennedy Krieger, Inc. 2023-05-31
NCT00692861 Autoimmunity in Neurologic Complications of Celiac Disease https://ClinicalTrials.gov/show/NCT00692861 Completed National Institutes of Health Clinical Center (CC) NA
NCT00654251 Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias https://ClinicalTrials.gov/show/NCT00654251 Completed University of Mississippi Medical Center 2009-02-28
NCT00056186 Transitional Life Events in Patients With Friedreich’s Ataxia: Implications for Genetic Counseling https://ClinicalTrials.gov/show/NCT00056186 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001324 PET Scan to Study Brain Control of Human Movement https://ClinicalTrials.gov/show/NCT00001324 Completed National Institutes of Health Clinical Center (CC) NA
NCT00006492 Gluten-Free Diet in Patients With Gluten Sensitivity and Cerebellar Ataxia https://ClinicalTrials.gov/show/NCT00006492 Completed National Institutes of Health Clinical Center (CC) NA
NCT00004306 Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10) https://ClinicalTrials.gov/show/NCT00004306 Completed Office of Rare Diseases (ORD) 2009-03-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03336008 Hong Kong Spinocerebellar Ataxias Registry https://ClinicalTrials.gov/show/NCT03336008 Recruiting Chinese University of Hong Kong 2019-12-31
NCT02701036 Sporadic Degenerative Ataxia With Adult Onset: Natural History Study https://ClinicalTrials.gov/show/NCT02701036 Recruiting Ataxia Study Group 2030-12-31
NCT02069509 Patient Registry of the European Friedreich’s Ataxia Consortium for Translational Studies (EFACTS) https://ClinicalTrials.gov/show/NCT02069509 Recruiting European Friedreich’s Ataxia Consortium for Translational Studies 2021-12-31
NCT01793168 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford https://ClinicalTrials.gov/show/NCT01793168 Recruiting Sanford Health 2100-12-31
NCT03885167 Identification of Biomarkers in Spinocerebellar Ataxia 3 https://ClinicalTrials.gov/show/NCT03885167 Active, not recruiting University of Michigan 2021-12-31
NCT03090789 FA Clinical Outcome Measures https://ClinicalTrials.gov/show/NCT03090789 Recruiting Children’s Hospital of Philadelphia 2030-01-01
NCT03418740 Neurology Measures in FA Children https://ClinicalTrials.gov/show/NCT03418740 Recruiting Children’s Hospital of Philadelphia 2021-12-31